A Simpler Synthesis of D-Pantothenic Acid 4'-Phosphate

Synthesis and properties of pantothenic acid monophosphates.

Although it appears most probable that coenzyme A is a phosphate derivative of pantothenic acid (2), little information is available as to the position or nature of the phosphate linkage in the molecule. It became of interest in this connection to examine the properties of simple phosphate derivatives of pantothenic acid, and for this purpose efforts were directed toward the preparation of the ...

Pantothenic acid synthesis by smooth Brucella abortus.

The relationship between formation of exogenous alanine and the establishment of nonsmooth variants in originally smooth cultures of Brucella abortus strains has been clearly demonstrated (Goodlow et al., 1950). Furthermore, the addition of D-alanine to smooth cultures in synthetic medium (Gerhardt and Wilson, 1948) results in earlier establishment of nonsmooth cells (Goodlow et al., 1951). Sub...

Pantothenic Acid – Applications, Synthesis and Biosynthesis

PANTOTHENIC ACID – APPLICATIONS, SYNTHESIS AND BIOSYNTHESIS (Abstract): Pantothenic acid, also known as vitamin B5 or anti-stress vitamin, is a water-soluble vitamin with various applications in pharmaceutical industry (ointments, solut ions for treating lesions and irritation of the skin or mucous membranes, multivitamin supplements tablets, capsules, effervescent tablets, chewable tablets, sy...

Heme synthesis in vitamin B6 and pantothenic acid deficiencies.

Shemin and coworkers (14) showed that the a-carbon and nitrogen atoms of glycine were precursors of specific atoms of the heme molecule. This was substantiated by Muir and Neuberger (5, 6). Other carbon atoms were shown to come from acetate (5-7) or succinate (8). The nature of the intermediate precursors synthesized from these metabolites remained unknown until the structure for urinary porpho...

Microbic Decomposition of Pantothenic Acid.